Blood Pressure in Salt-Sensitive Dahl Rats

Introduction

Salt-sensitive hypertension is known to be associated with dysfunction of the baroreflex control system in the Dahl salt-sensitive (SS) rat. However, neither the physiological mechanisms nor the genomic regions underlying the baroreflex dysfunction seen in this rat model are definitively known. Here, we have adopted a mathematical modeling approach to investigate the physiological and genetic origins of baroreflex dysfunction in the Dahl SS rat. We have developed a computational model of the overall baroreflex heart rate control system based on known physiological mechanisms to analyze telemetry-based blood pressure and heart rate data from two genetic strains of rat, the SS and consomic SS.13BN, on low- and high-salt diets. With this approach, physiological parameters are estimated, unmeasured physiological variables related to the baroreflex control system are predicted, and differences in these quantities between the two strains of rat on low- and high-salt diets are detected. Specific findings include: a significant selective impairment in sympathetic gain with high-salt diet in SS rats and a protection from this impairment in SS.13BN rats, elevated sympathetic and parasympathetic offsets with high-salt diet in both strains, and an elevated sympathetic tone with high-salt diet in SS but not SS.13BN rats. In conclusion, we have associated several important physiological parameters of the baroreflex control system with chromosome 13 and have begun to identify possible physiological mechanisms underlying baroreflex impairment and hypertension in the Dahl SS rat that may be further explored in future experimental and modeling-based investigation.

Pressure-Time series Data

The four *.txt (text) files below contain continuous blood pressure recordings for 9 Dahl SS rats and 6 Dahl SS.13BN rats, under high and low salt conditions. Read the comments at the top of each file for details.

For convenience, the data contained in the original text files are also available in standard PhysioBank format, suitable for study using the WFDB Software Package. Each pair of (binary) *.dat and (text) *.hea files below comprises a PhysioBank-format record that contains data from a single rat, extracted from the *.txt files.

Usage

These data are freely distributed for noncommercial use in research and education.