Cerebromicrovascular Disease in Elderly with Diabetes 1.0.1

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Visit	Physionet	Directory	Filename	Format	Channels	Sampling rate	Label	description	units	Calibration	Equipment	Calibration/Device output sampling rate	Experiment	Visit	Files
Screening	Not uploaded	Screening	Medical history
			TCD window
			Blood draw
			MMSE
			PCP permission

Screening	Data/ECG	24 hour ECG and EMG monitoring	ECG	ME6000	ME6000 files (ECG and EMG files were recorded during the protocol walking test, and during the daily activity and sleeping)
			12 min walk			ME6000	5	1000Hz
			sleep		S####ECG.dat
					S####ECG.hea		1		ECG 1	CH1 V5/V6-L clavicle
							2		ECG 2	CH2 V1/V2 L clavicle
							3		foot switch	right
							4		foot switch	left
							5		EMG	gastrocnemius right
							6		EMG	gastrocnemius left
							7		accelerometer
							8		empty

Visit 1/Day 1	Not uploaded	Retinal Imaging	Retinal Imaging

Visit 1/Day 1	Not uploaded	Cognitive testing	Cognitive

Visit 1/Day 2	Data/labview	Labview	Head up tilt	Vasoreactivity, Valsalva maneuver, Head up tilt
			with TCD
			Valsalva manuever
			5 min supine baseline		S####DA.dat	Labview	10	500 Hz						Visit 2
			3 min hyperventilation		S####DA.hea										Baseline values of Day 1 and Day 2 Procedures.
			3 min CO2 rebreathing				1		Marker					Visit 8
			5 min supine rest				2		ECG						24-months Follow-up values of Day 1 and Day 2 Procedures.
			Head up tilt 10 min				3		ABP			*100
							4		Mcar
							5		Mcal
							6		Radi
							7		Therm
							8		Flow
							9		O2			*9.09
							10		.CO2			*7.74

Visit 1/Day1	Not uploaded	24-hr-bp	24 hour BP monitoring	text	24 hour BP	20 min day, 30 min night
					Automated BP measurements every 20 min during daytime and at 30 min at night for 24 hours

					SxxxxA.R	raw file	1		date
					SxxxxA.V	validated file	2		time
							3		status
					SxxxxB.R	second recording	4		systolic blood pressure
							5		diastolic blood pressure
							6		mean blood pressure
							7		heart rate
					header subject ID, date, start time, end time, systolic and diastolic data threshold

Visit 1/Day 1	Not uploaded	portapres-new	Portapress resting continuous beat-to-beat BP for 1.5/2 hours in supine or sitting position
		portapres		Portapress
		beatscope-program
	Continuus beat-to-beat BP monitoring in reclining sitting or supine position for 1.5 - 2 hours while subject is resting using beatscope program.
					Sxxxxsabeat1-x.dat	binary proprietary format	3	100Hz		files have anout 300-500 KB about 2 hours
					Sxxxxsa1-x.dat		1		time ( seconds)
					Sxxxxsb1-x.dat		2		Porta	finger blood pressure waveform	mmHg
							3		Height		mmHg





Day 1	Not uploaded	Pedar	Walk test 1&2 ( walk1 around 11 am and walk 2 in the afternoon, normal hallway walking for 12 min recorded with EMG channels using ME6000) and foot pressure distribution using pedar moile, some subjects also have Portapress beat-to-beat blood pressure								ME6000
			Walking test- foot pressure distribution and walking characteristics using Pedar Mobile
					SxxxxS-1.asc	Pedar	99				N/cm2	calibrated	Pedar Mobile X, Novel , Munich GE	50 Hz
					SxxxxA-1.asc	ascii	1	filename Xxxxx-1*.sol			s
							2	insole type			%
							3	date/time
							4	total time	(seconds)
							5	time per frame	(s econds : 0.02)
							6	pressure values in N/cm2
							7	mask definition	( e.g.M1)
							channel 8-99	sensor values

					SxxxxA-9rg	text		map of 9 regions
					note filenames inconsistent but this is calibration file for each recording
					SxxxxS-1.gtc	text	16
					SxxxxSA-1.gtc.xls	Excel	header: filename, left insole #, right insole #, mean step left, mean step right, min and max step, total time (s econds), distance ( meters),velocity (m/s)
							1	step #
							2	foot ( 1,2)
							3	max force (N)
							4	mean force (N)
							5	max pressure [N/cm2]
							6	start
							7	start in % of total time
							8	stride
							9	step #
							10	stance
							11	stance in % of stride
							12	swing
							13	swing % init
							14	double in %
							15	single limb support
							16	terminate double support %




Day 2	data/labview	Labview	Vasoreactivity, Valsalva maneuver, Head up tilt
	with TCD	TCD

			Valsalva manuever
			5 min supine baseline		S####DB.dat	Labview	10	500 Hz			V
			3 min hyperventilation		S####DB.hea
			3 min CO2 rebreathing				1		marker						baseline	Valsalva maneuver	hyperventilation	Co2 rebreathing	head-up tilt	baseline
			5 min supine rest				2		ECG	ECG
			Head up tilt 10 min				3		ABP	finger blood pressure waveform	mmHg	*100	Finapress	100 HZ
							4		Mcar	right middle cerebral artery flow velocity waveform	cm/s		Multi
							5		Mcal	left middle cerebral artery flow velocity waveform	cm/s		MultiDop X4, DWL Neuroscan Inc, Sterling, VA;	50 Hz
							6		Radi	radial artery flow velocity waveform	c,/s
							7		Thermst	respiration with nasal thermistor	relative		thermisor
							8		Flow rate	respiration flow rate	???		Capnomac Ultima
							9		O2	end tidal O2	mmHg	*9.09	Capnomac Ultima
							10		CO2	end tidal CO2	mmHg	*7.74	Capnomac Ultima


Day 2	data/labview	labview-sit-to-stand	Sit-to-stand Test
	5 min sitting with eyes open on balance platform with simultaneous cardiovascular, TCD
	5 min standing with eyes open on balance platform with simultaneous cardiovascular, TCD and balance measures
	5 min sitting with eyes closed on balance platform with simultaneous cardiovascular, TCD
	5 min standing with eyes closed on balance platform with simultaneous cardiovascular, TCD and balance measures
					S####DC.dat	Labview	15	1000 Hz			V
					S####DC.hea
							1		marker						sitting 5min	standing eyes open 3min	sitting	standing eyes closed
							2		ECG	ECG
							3		ABP	finger blood pressure waveform	mmHg	*100	Finapress
							4		Mcar	right middle cerebral artery flow velocity waveform	cm/s		Multi
							5		Mcal	left middle cerebral artery flow velocity waveform	cm/s		MultiDop X4, DWL Neuroscan Inc, Sterling, VA;
							6		Radi	radial artery flow velocity waveform	cm/s
							7		Thermst	respiration with nasal thermistor	relative		thermisor
							8		Flow rate	respiration flow rate	ml/s		Capnomac Ultima
							9		O2	end tidal O2	mmHg	*9.09	Capnomac Ultima
							10		CO2	end tidal CO2	mmHg	*7.74	Capnomac Ultima
							11		fx	sway trajectory in mediolateral direction	mm		Kistler Force plate, Amherst MA
							12		fy	sway trajectory in anteroposterior direction	mm
							13		fz	sway trajectory in vertical direction	mm
							14		px	center of pressure x component	mm
							15		py	center of pressure x component	mm

					S#####DC.ch1-10.dat	Labview	10	1000 Hz

							1		marker
							2		ECG	ECG
							3		ABP	finger blood pressure waveform	mmHg	*100	Finapress
							4		Mcar	right middle cerebral artery flow velocity waveform	cm/s		Multi
							5		Mcal	left middle cerebral artery flow velocity waveform	cm/s		MultiDop X4, DWL Neuroscan Inc, Sterling, VA;
							6		Radi	radial artery flow velocity waveform	cm/s
							7		Thermst	respiration with nasal thermistor	relative		thermisor
							8		Flow rate	respiration flow rate	ml/s		Capnomac Ultima
							9		O2	end tidal O2	mmHg	*9.09	Capnomac Ultima
							10		CO2	end tidal CO2	mmHg	*7.74	Capnomac Ultima





	Not uploaded	anatomial and perfusion MRI	output	MRI- anatomical, CBF regional perfusiona dn paerfusion in vascular territories; CO2 vasoreactivity to hyperventilation and C02 rebreathing
				processed data are available in the summary Table	3Tesla GE Signa Vhi or Excite scanner and phase arrays head coil ( GE Medical Systmes, Milwaukee, WI)
				MP-RAGE
								MP-RAGE) (repetition	ml or % of total brain volume
								time [TR]/echo time [TE]/inversion time [TI] 7.8/3.1/600
								msec, 3.0 mm slice thickness, 52 slices, bandwidth 122 Hz
								per pixel, flip angle 10°, 24 cm 24 cm field of view [FOV],
								256 192 matrix size)

			FLAIR					fluid-attenuated inversion recovery
								(FLAIR) (TR/TE/TI 11,000/161/2,250 msec, 5 mm slice
								thickness, 30 slices, bandwidth 122 Hz per pixel, flip angle
								90°, 24 cm 24 cm FOV, 256 160 matrix size),

			DWI					diffusion-weighted image (b value of 1,000 seconds/
								mm2, TR/TE 10,000/86.6 msec, 5 mm slice thickness, bandwidth
								250 kHz, 128 128 matrix size

			CASL	CBF				three-dimensional stack of	mL · 100 g1 · min1
								interleaved spirals fast spin echo sequence (TR/TE 6,000/
								23.8 msec, echo train length 66, with a 18 18 cm FOV, in
								the coronal plane and 64 slices with thickness 3.8 mm, eight
			see Zhao et al. Neurology 2009 ;72:643-649 for procecessing details					spiral interleaves, two averages and a bandwidth62.5 kHz).
			Transcranial Doppler
				TCD exported ALL
			SxxxSB.xl0	ascii	11 channels			baseline, Valsalva menuever, head up tilt
			Sxxx sb.xl1 sit-to-stand test					sit-to-stand test
								time
								MCAR Mean- Blood Flow velocity in right middle cerebral artery
								MCAR empty
								MCAR-empty
								MCAL -Mean Blood Flow velocity in the left middle cererbal artery
								BRAR- blood flow velocity in the brachial artery
								ABP- fingernoninvasive blood pressure waveform
								CO2- tidal CO2 ??
								ET CO2- end tidal expiratory CO2
								RSP- respiratory waveform
								ECG