Cerebral perfusion and cognitive decline in type 2 diabetes 1.0.1

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Visit	Physionet	Directory	Protocol	Filename	Format	Channels	Sampling rate	Label	description	units
Screening	Not uploaded	Screening	ICF
			TCD window
			Blood draw
			PCP permission

Screening	Data/ECG	24 hour ECG and EMG monitoring	me6000	ME6000 files (ECG and EMG files were recorded during the protocol walking test, and during the daily activity and sleeping)
		12 min walk			ME6000	5	1000Hz
		sit-to-stand test		S####ECG.dat
		sleep		S####ECG.hea		1		ECG 1	CH1 V5/V6-L clavicle
						2		ECG 2	CH2 V1/V2 L clavicle
						3		foot switch	right
						4		foot switch	left
						5		EMG	gastrocnemius right
						6		EMG	gastrocnemius left
						7		accelerometer
						8		empty

Visit 1	Not uploaded	Retinal Imaging	Retinal Imaging

Visit 1	Not uploaded	Cognitive testing	Cognitive

Visit 1	Data/Pedar	Pedar	12 minute walk	Walk test 1&2 ( walk1 around 11 am and walk 2 in the afternoon, normal hallway walking for 12 min recorded with EMG channels using ME6000)
				and foot pressure distribution using pedar moile, some subjects also have Portapress beat-to-beat blood pressure

				Walking test- foot pressure distribution and walking characteristics using Pedar Mobile
				S####DA.ASC_Pedar	DAT
				S####DA.ASC_Pedar	HEA
						16
						header: filename, left insole #, right insole #, mean step left, mean step right, min and max step, total time (s econds), distance ( meters),velocity (m/s)
						1	step_no
						2	foot
						3	max. force[N]
						4	mean force[N]
						5	max pressure [N/cmÂ²]
						6	start
						7	start in % of total time
						8	stride
						9	step
						10	stance
						11	stance in % of stride
						12	swing
						13	swing in %
						14	init double in %
						15	single limb support %
						16	terminate double %

Visit 2	Data/labview	Labview	Head up tilt	Vasoreactivity, Valsalva maneuver, Head up tilt
		with TCD	TCD

		Valsalva manuever
		5 min supine baseline		S#####DB.dat	Labview	10	500
		3 min hyperventilation
		3 min CO2 rebreathing				1		Marker
		5 min supine rest				2		ECG
		Head up tilt 10 min				3		ABP
						4		Mcar
						5		Mcal
						6		Radi
						7		Therm
						8		Flow
						9		O2
						10		Co2


Day 2	data/labview	labview-sit-to-stand	Sit-to stand with eyes open and closed
		5 min sitting with eyes open on balance platform with simultaneous cardiovascular, TCD
		5 min standing with eyes open on balance platform with simultaneous cardiovascular, TCD and balance measures
		5 min sitting with eyes closed on balance platform with simultaneous cardiovascular, TCD
		5 min standing with eyes closed on balance platform with simultaneous cardiovascular, TCD and balance measures
				S#####DC.dat	Labview	15	1000

						1		Marker
						2		ECG
						3		ABP
						4		Mcar
						5		Mcal
						6		Radi
						7		Therm
						8		Flow
						9		O2
						10		Co2
						11		fx
						12		fy
						13		fz
						14		px
						15		py

Day 2	Not uploaded	3TMRI	Anatomial and perfusion MRI	MRI- anatomical, CBF regional perfusiona dn paerfusion in vascular territories; CO2 vasoreactivity to hyperventilation and C02 rebreathing
						3Tesla GE Signa Vhi or Excite scanner and phase arrays head coil ( GE Medical Systmes, Milwaukee, WI)
				MP-RAGE
									MP-RAGE) (repetition	ml or % of total brain volume
									time [TR]/echo time [TE]/inversion time [TI] 7.8/3.1/600
									msec, 3.0 mm slice thickness, 52 slices, bandwidth 122 Hz
									per pixel, flip angle 10°, 24 cm 24 cm field of view [FOV],
									256 192 matrix size)

				FLAIR					fluid-attenuated inversion recovery
									(FLAIR) (TR/TE/TI 11,000/161/2,250 msec, 5 mm slice
									thickness, 30 slices, bandwidth 122 Hz per pixel, flip angle
									90°, 24 cm 24 cm FOV, 256 160 matrix size),

				DWI					diffusion-weighted image (b value of 1,000 seconds/
									mm2, TR/TE 10,000/86.6 msec, 5 mm slice thickness, bandwidth
									250 kHz, 128 128 matrix size

				CASL	CBF				three-dimensional stack of	mL · 100 g1 · min1
									interleaved spirals fast spin echo sequence (TR/TE 6,000/
									23.8 msec, echo train length 66, with a 18 18 cm FOV, in
									the coronal plane and 64 slices with thickness 3.8 mm, eight

				Transcranial Doppler