ECG Effects of Ranolazine, Dofetilide, Verapamil, and Quinidine 1.0.0
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Column Description
EGREFID Unique ECG ID (same as file name)
RANDID Subject Randomization number
SEX Sex either M (Male) or F (Female)
AGE Age in years at screening
HGHT Height in cm at screening
WGHT Weight in kg at screening
SYSBP Baseline systolic blood pressure in mmHg (across visits)
DIABP Baseline diastolic blood pressure in mmHg (across visits)
RACE Race as provided
ETHNIC Ethnicitiy as provided
ARMCD Sequence of treatments using treatment codes (A: Ranolazine, B: Dofetilide, C: Verapamil, D: Quinidine, E: Placebo)
VISIT Visit code, PERIOD-X-Dosing refers to the X'th dosing
EXTRT Treatment
EXDOS Dose of treatment
EXDOSU Unit of dose
TPT Nominal time-point, relative to dose. ECGs from the same nominal time-point or triplicate have same time-point
BASELINE Baseline Y/N
PCTEST Pharmacokinetic test
PCSTRESN Measured concentration or missing if no measurement were performed, this is the case for baseline. As only one sample were performed for each nominal time-point the value is repeated for all ECGs
PCSTRESU Units of measured concentration
EGREFID Unique ECG id. ECGs are stored within the zipfiles as follows: randid/egrefid.ecg
RR RR interval in ms
PR PR interval in ms
QT QT interval in ms
QRS QRS interval in ms
JTPEAK J-Tpeak interval in ms (from end of QRS to the first peak of the T-wave)
TPEAKTEND Tpeak-Tend interval in ms (from the first peak of the T-wave to the end of the T-wave)
TPEAKTPEAKP Interval between the two peaks of the T-wave (if secondary peak is present in the T-wave) in ms
ERD_30 30% of early repolarization duration in ms
LRD_30 30% of late repolarization duration in ms
Twave_amplitude Amplitude of the T-wave measured in the vector magnitude lead in uV
Twave_asymmetry T-wave asymmetry score (dimensionless units)
Twave_flatness T-wave flatness score (dimensionless units)