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It is possible, with appropriate (SLIP, PPP, or TERM) software, to run WAVE across a serial connection (see the previous question for details), but this will be rather slow even with a 56 kbps modem. Using WAVE remotely via Ethernet is usually quite tolerable, however.
If you run WAVE locally, but read data from a remote web site such as PhysioNet, you will have much better performance, whether using a modem or Ethernet, because the volume of data transferred is far lower in this case.